Cipher: 2120
Nomenclature: Application of biomaterials in medical science
Study programme: Molecular biosciences
Module: Materials science and new technologies
Case holder:

Assoc. prof.dr.sc. Željka Perić Kačarević
Assoc. prof.dr.sc. Marko Matijević
Institution of the case holder:

Faculty of Dental Medicine and Health Osijek, J.J. Strossmayer University in Osijek
Contributors - Contractors:

Doc.dr.sc. Mike Barbeck
Subject status: Electoral College
The year in which the case is submitted: Year I
The semester in which the case is submitted: Semester II
Subject objective:

Get acquainted with biomaterials and their future in the world and expand personal knowledge about animal and humane scientific research and the functioning of the cellular response of tissues to the ingested biomaterial.
Case contents:

Implants, structure, shapes and properties of biomaterials. Application and technological development of biomaterials and the future of 3D printing of biomaterials in combination with collagen or hyaluronic acid. From the idea to the performance of the product and its scientific analysis.
In vitro i in vivo. Interaction of biomaterials in animal studies. Subcutaneous implantation and analysis of soft tissue biomaterials and cranial implantation and analysis of solid tissue biomaterials. Remodelation of bones under the influence of various materials as an immune response of macrophages to infection caused by implantation injury. The role of macrophages and MNGC in the decomposition of biomaterials as well as the osteiductivity of them.
Learning outcomes: competences, knowledge, skills that the subject develops:

1. Predict the possible use of biomaterials.
2. Analyse basic scientific knowledge about the structure and function of biomaterials.
3. Establish the principle of material analysis from ideas, inventions, implantation and cellular response.
4. Propose a scientific study of the analysis of biomaterials in dental application.
ECTS Credits 6
Lectures 20
Seminars (IS) 5
Exercises (E) 0
Altogether 25
The way of teaching and acquiring knowledge:

Students need to attend lectures and exercises or consultations, and prepare an analysis of the scientific work of their choice from the topic of the subject.
Ways of teaching and acquiring knowledge: (notes)
Monitoring and evaluating students (mark in fat printing only relevant categories) Attendance, Teaching activities, Mandatory seminar work
Rating method: Oral exam, Essay/Seminar, Continuous examination of knowledge in the course of teaching
Mandatory literature:

1. Rosario Pignatello et al. Biomaterials Science and Engineering. InTech Open. 2011 Available at: http://www.issp.ac.ru/ebooks/books/open/Biomaterials_Science_and_Engineering.pdf
2. Roi A, Ardelean LC, Roi CI, Boia ER, Boia S, Rusu LC. Oral Bone Tissue Engineering: Advanced Biomaterials for Cell Adhesion, Proliferation and Differentiation. Materials (Basel). 2019 Jul 18,12(14).
3. Elgali I, Omar O, Dahlin C, Thomsen P. Guided bone regeneration: materials and biological mechanisms revisited. Eur J Oral Sci. 2017 Oct;125(5):315-337.
4. Patrick Rider, Željka Perić Kačarević, Sujith Retnasingh, Said Alkildani, Ole Jung, Mike Barbeck. Bioprinting. InTech Open. 2018 Available at: https://www.intechopen.com/books/biomaterial-supported-tissue-reconstruction-or-regeneration/bioprinting
Supplementary (recommended) literature:

1. Perić Kačarević Z, Kavehei F, Houshmand A, Franke J, Smeets R, Rimashevskiy D, Wenisch S, Schnettler R, Jung O, Barbeck M. Purification processes of xenogeneic bone substitutes and their impact on tissue reactions and regeneration. Int J Artif Organs. 2018 Nov.41(11):789-800.
2. Rider P, Kačarević ŽP, Alkildani S, Retnasingh S, Barbeck M. Bioprinting of tissue engineering scaffolds. J Tissue Eng. 2018 Oct 8;9.
3. Rider P, Kačarević ŽP, Alkildani S, Retnasingh S, Schnettler R, Barbeck M. Additive Manufacturing for Guided Bone Regeneration: A Perspective for Alveolar Ridge Augmentation. Int J Mol Sci. 2018 Oct 24,19(11).
4. Haugen HJ, Lyngstadaas SP, Rossi F, Perale G. Bone grafts: which is the ideal biomaterial? J Clin Periodontol. 2019 Jun;46 Suppl 21:92-102.
How to monitor the quality and performance performance (evaluation):

The success of the course will be evaluated annually by the joint expert committee of the Ruđer Boskovic Institute, the University of Dubrovnik and the University of Josip Juraj Strossmayer in Osijek based on exam success and surveys.