Cipher: 2621
Nomenclature: Liver pathophysiology
Study programme: Molecular biosciences
Module: Biomedicine
Case holder:

Prof.dr.sc. Alexander Vchev
Prof.dr.sc. Martina Smolić
Institution of the case holder:

Faculty of Dental Medicine and Health, J.J. Strossmayer University of Osijek
Contributors - Contractors:

Prof.dr.sc. Branko Dmitrović
Doc.dr.sc. Anđela Grgić
Izv.prof.dr.sc. Ljiljana Trtica Majnarić
Subject status: Electoral College
The year in which the case is submitted: Year I
The semester in which the case is submitted: Semester II
Subject objective:

Understand the anatomy, histology and pathology of the liver and liver diseases, their pathophysiology, clinical features as well as methods of treatment.
Case contents:

Anatomy and liver histology. Liver physiology. Emphasized importance of cellular biology as a fundamental approach to understanding the structure and function of tissues and organs. Medical examples suggesting a link between histology and pathobiology, diagnostics and clinical forms of liver disease.
Disorders of intermediate liver metabolism. Disorders of the hepatic function of synthesis. Detoxification disorders. Metabolic disorders and excretion of bilirubin. Disorders of bile circulation. Acute and chronic hepatitis. Chronic liver disease. Metabolic syndrome and non-alcoholic fatty liver disease. Cirrhosis of the liver. Bile liver disease. Liver tumors.
A history and physical examination of a person with liver disease. Laboratory findings for liver disease. New findings in the treatment of liver disease.
Learning outcomes: competences, knowledge, skills that the subject develops:

1. Explain the anatomical, histological and pathological structure of the liver.
2. To determine the association of the most common liver diseases with their main symptoms with the pathophysiological processes underlying.
3. Predict anatomical, pathohistological and pathophysiological events in the most important liver diseases.
4. Judge the most appropriate treatments based on pathophysiological changes and clinical findings.
ECTS Credits 6
Lectures 20
Seminars (IS) 5
Exercises (E) 5
Altogether 30
The way of teaching and acquiring knowledge:

Regular attendance and preparation of seminar work.
Ways of teaching and acquiring knowledge: (notes)
Monitoring and evaluating students (mark in fat printing only relevant categories) Attendance, Teaching activities, Mandatory seminar work
Rating method: Oral exam, Essay/Seminar
Mandatory literature:

1. Selected chapters from the textbook Duale Reihe: Anatomy (your. hrv. editions: I. Vinter, V. Katavić, Z. Petanjek), Medical Publishing Zagreb, 2018.
2. Junqueira Cl, Carneiro J. Basics of histology: textbook and atlas. Zagreb: Medical publishing 2005.
3. Damjanov I, Seiwerth S, Jukić S, Nola M. Pathology. 5th edition. Zagreb: Medical circulation 2017
4. Damian's I. Patophysiology. 1. ed. Philadelphia: Elsevier; 2009.
5. Katzung B. Basic and clinical pharmacology. Zagreb: Medical publishing; 2011.
Supplementary (recommended) literature:

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How to monitor the quality and performance performance (evaluation):

The success of the course will be evaluated annually by the joint expert committee of the Ruđer Boskovic Institute, the University of Dubrovnik and the University of Josip Juraj Strossmayer in Osijek based on exam success and surveys.