Cipher: 2607
Nomenclature: Gene treatment: Experimental and clinical aspects
Study programme: Molecular biosciences
Module: Biomedicine
Case holder:

Doc.dr.sc. Katarina Mišković Špoljarić
Doc.dr.sc. Saska Marczi
Institution of the case holder:

Faculty of Medicine, J.J. Strossmayer University of Osijek
Contributors - Contractors:

Doc.dr.sc. Teuta Opačak Bernardi
Subject status: Electoral College
The year in which the case is submitted: Year I
The semester in which the case is submitted: Semester II
Subject objective:

To know the latest developments in research and clinical application of gene, molecularly oriented, treatment.
Case contents:

General principles of gene treatment; Principles of molecularly oriented treatment; Portable systems (non-peviral, viral, artificially designed); Therapeutic agents (ribosimes, aptamers, catalytic DNA); Molecular chemotherapy; Mutation correction; Stimulating the immune reaction; Stimulation/elimination of drug resistance; The use of stem hematopoietic cells for gene treatment; Clinical use in the treatment of tumor patients; Clinical use in the treatment of monogenic and neurodegenerative diseases; Combined use of chemotherapy and gene treatment; Gene treatment of mitochondrial diseases; Use of telomerase in the treatment of tumor patients; Ethical principles
Learning outcomes: competences, knowledge, skills that the subject develops:

1. Establish the general principles of gene treatment.
2. Analyze knowledge about the latest developments in gene treatment research based on professional and scientific literature.
3. Explain the clinical applications of gene, molecularly oriented, treatment.
4. Propose the use of gene, molecularly oriented, treatment in new situations.
5. Discuss the ethical principles of gene treatment.
ECTS Credits 4
Lectures 15
Seminars (IS) 5
Exercises (E) 0
Altogether 20
The way of teaching and acquiring knowledge:

regular attendance, mandatory seminar work
Ways of teaching and acquiring knowledge: (notes)
Monitoring and evaluating students (mark in fat printing only relevant categories) Attendance, Teaching activities, Mandatory seminar work
Rating method: Written exam, Oral exam
Mandatory literature:

Pavelić J, Slade N, Galetic I, Pavelić K: Gene treatment: principles, ranges and perspectives. Pharmaca, 36:151-170, 1998.

Hicke BJ, Stephens AW: Escort aptamers: a delivery service for diagnosis and therapy. J Clin Invest 106: 923-928, 2000.

Baum C, Fairbairn LJ, Hildinger M, et al.: New perspectives for cancer chemotherapy by genetic protection of haematopoietic cells. Expert Reviews in Molecular Medicine, http://www-ermm.cbcu.cam.ac.uk

Horig H, Medina FA, Conkright WA, et al.: Strategies for cancer therapy using carcinoembryonic antigen vaccines. Expert Reviews in Molecular Medicine, http://www-ermm.cbcu.cam.ac.uk

Mann M, Dzau VJ: Therapeutic application of transcription factor decoy oligonucleotides. J Clin Invest, 106:1071-1075.

Kerr D. Clinical development of gene therapy for colorectal cancer. Nature Rev., 3:615, 2003.

Kohn DB et al. Occurence of leukaemia following gene therapy of X-linked SCID. Nature Rev., 3:477 a.m., 2003.

Kohn DB et al. Occurence of leukaemia following gene therapy of X-linked SCID. Nature Rev., 3:477 a.m., 2003.
Supplementary (recommended) literature:

WEBSITES
How to monitor the quality and performance performance (evaluation):

For individual lectures - Checking the understanding of the information obtained and how to present it.
For the course - Examining the adequacy of the program, the method of presentation, the teaching materials.
Discussions with students and colleagues.
Evaluation of performance by the head of studies and the joint expert committee of the institutions of the holders of the study.
The success of the course will be evaluated annually by the joint expert committee of the Institute "Ruđer Bošković", the University of Dubrovnik and the University of Osijek.