Cellular Signal Transmission (2313)

Assoc. Prof. Dr. Sc. Miroslav Lisjak
Prof.dr.sc. John T. Hancock

(ML) Faculty of Agrobiotechnical Sciences, Josip Juraj Strossmayer University
(JTH.) University of the West of England, Bristol, UK - Faculty of Applied Sciences

To understand the importance of understanding the cellular transmission of signals and the signaling mechanism in the investigation of different biological systems.

1. Signal transmission review: aspects of cellular signaling; Signal transmission routes; History and techniques of cell signaling testing. 2. Components of the signaling pathways - hormones, cytokines and growth factors; Detection of extracellular signals - the role of receptors; Phosphorylation of proteins, kinases and phosphatase; Cyclic nucleotides, cyclases and G proteins; Metabolism of inositol phosphate and the role of membrane lipids; Intracellular calcium as an intracellular signal; ROS, RNS and redox signaling. 3. Examples of signaling pathways and manifestations: Insulin and the signal transmission cascades it arouses; Environmental perception; Signaling during development and for the regulation of gene expression; Life, death and apoptosis. 4. Cellular transmission of signals: significance, complexity and future. 5. Seminar: overview of the latest literature related to signal transmission in plant, animal and human cells.

1. Analyze the main principles of cellular transmission of signals as well as the constituent molecular components of individual signal transmission pathways in the cell that are basically very similar in a wide range of different organisms.
2. Compare the "up-" and "downstream" pathways of cell signal movement and at the molecular level of the specific reaction of the components involved in the cascade of signal transmission in certain signaling pathways.
3. Predict the interaction of signaling pathways in a complex network of cell signal transmission.
4. Critically judge the current scientific literature from the issue of cellular transmission of signals (and apply it to their research models).

Students are obliged to attend lectures or consultations and exercises (practicum) and to prepare and exhibit seminar work.

1. Hancock, J. T. (2010): Cell signalling. 3rd edition, Oxford University Press. 352 p.
2. Hancock, J. T. (ed.) (2009): Redox-mediated signal transduction. Methods and protocols. Series "Methods in molecular biology"; Humana press," vol. 476. 234 p.
3. Neill, S., Hancock, J.T., Wilson, I.D. (2009): Oxygen Species, nitric oxide and signal crosstalk. In: Yoshioka, K. and Shinozaki, K., (eds.) Signal crosstalk in plant stress responses. Wiley-Blackwell, pp. 136-160.

1.Marks, F., Klingmuller, U., Muller-Decker, K. (2009) Cellular Signal Processing. Garland Science. 634 p.
2.Alberts et al. (2008) 5th Ed. Molecular Biology of the Cell. Garland Publishing. 1392p.
3.Hancock, J.T. (2009): The role of redox mechanisms in cell signalling. Molecular Biotechnology 43, 162-166.
4.Hancock, J.T. (2009): Cell signalling is the music of life. Brit. J. Biomed. Sci., 65, p. 205-208.
5.Wilson, I., Neill, S.J., Hancock, J.T. (2008): Nitric oxide signalling in plants. Plant Cell Environment 31, p. 622-631.
6.Simon Hiscock, S., Bright, J., McInnis, S.M., Desikan, R., Hancock, J.T. (2007): Signalling on the Stigma: Potential New Roles for ROS and NO in Plant Cell Signaling. Plant Signalling and Behaviour, 2(2), p. 23-24.

Interview with students and colleagues - filling out questionnaires after completing the lecture
Evaluation of each student.
The success of the course will be evaluated annually by the joint expert committee of the Ruđer Boskovic Institute, the University of Dubrovnik and the University of Josip Juraj Strossmayer in Osijek based on exam success and surveys.