Cipher: 2617
Nomenclature: Basics of nutrigenomics
Study programme: Molecular biosciences
Module: Biomedicine
Case holder:

Prof.dr.sc. Ljubica Glavaš-Obrovac
Institution of the case holder:

Faculty of Medicine, Josip Juraj Strossmayer University of Osijek
Contributors - Contractors:

Doc.dr.sc. Goran Ćurić
Izv.prof.dr.sc. Mario Štefanić
Doc.dr.sc. Teuta Opačak Bernardi
Subject status: Electoral College
The year in which the case is submitted: Year I
The semester in which the case is submitted: Semester II
Subject objective:

Understand how at the molecular level food ingredients affect human health directly or indirectly altering gene expression, metabolic pathways and homeostatic control.
Case contents:

What is nutrigenomics and the role of micronutrients and macronutrients in metabolism; Transcription factors and how they can mediate in food-gene interactions; The immune response of the organism in the disease; Signaling pathways and signal transmission in tumor diseases and inflammatory reactions; Nutrition and genes combined with the formation of tumors. Tools for the analysis of genomes and their application in nutrigenomics; The basics of bioinformatics and how to make data useful to biologists; Polymorphism in genes and sensitivity of genotypes to the type of diet; Molecular biomarkers; Functional food and adaptation of nutrition to the sensitive genotype.; The role of nutraceuticals in improving health and the mechanism of their action; Benefits and questionable effects of nutraceuticals.
Learning outcomes: competences, knowledge, skills that the subject develops:

1. Explain the basics of genetics, genomics and gene regulation in relation to nutrition.
2. Analyze the molecular aspects and regulation of food metabolism.
3. To determine the association of polymorphisms in genes with the sensitivity of individual genotypes to the type of diet, and therefore to changes in genes important in tumorigenesis.
4. Critically extract relevant data and information from literature in the field of molecular nutrition and nutrigenomics for the purpose of researching the effects of nutrition on the development of diseases.
ECTS Credits 5
Lectures 20
Seminars (IS) 5
Exercises (E) 0
Altogether 25
The way of teaching and acquiring knowledge:

Student obligations:
In order to successfully master the goals of this subject, the student should regularly attend classes, actively participate in "problem-solving" seminars (e-learning), follow the literature in the field, use genomic databases, discuss with other students about the topics of lectures and prepare a presentation.
Ways of teaching and acquiring knowledge: (notes)
Monitoring and evaluating students (mark in fat printing only relevant categories) Teaching activities, Mandatory seminar work
Rating method: Written exam, 9
Mandatory literature:

1. L. R. Ferguson (Ed). Nutrigenomics and Nutrigenetics in Functional Foods and Personalized Nutrition, 1st Ed, 2013.
2. S.S. Gropper, J.L. Smith, J.L. Groff: Advanced Nutrition and Human Metabolism, 4th Ed, 2005;
Supplementary (recommended) literature:

1. T. Brody: Nutritional Biochemistry, 1st Ed, Academic Press, San Diego, USA, 1999.
2.M.H. Stipanuka: Biochemical and Physiological Aspects of Human Nutrition, 1st Ed, W.B. Sanders, 2000.
3. J.M. Ordovas, D. Corella: Nutritional genomics. Ann. Rev. Genomics Human Genetics. 5, 71-118, 2004.
4. Martin Kussmann; Laurent B. Fay. Nutrigenomics and Personalized Nutrition: Science and Concept. Personalized Medicine. 2008;5(5):447-455.
How to monitor the quality and performance performance (evaluation):

Check the understanding of the information received, the presentation method and the scope of the material adopted by using the questionnaire at the end of the lecture of the subject
Discussions with students and colleagues
The success of the course will be evaluated annually by the study leadership and the joint expert committee of the institutions of the holders of the study