Cipher: 2604
Nomenclature: Metabolic genetic changes in acute, chronic and malignant diseases of the pancreas
Study programme: Molecular biosciences
Module: Biomedicine
Case holder:

Assoc. prof.dr.sc. Neda Slade, zn. Advisor in permanent selection
Institution of the case holder:

Ruđer Boskovic Institute
Contributors - Contractors:

Assoc. prof.dr.sc. Neda Slade, zn. Counsellor
Subject status: Electoral College
The year in which the case is submitted: Year I
The semester in which the case is submitted: Semester II
Subject objective:

Understand metabolic and genetic changes associated with the emergence and progression of acute, chronic and malignant diseases of the pancreas with an emphasis on etiology, mechanisms of the emergence and development of the disease, and discuss possible new therapeutic approaches.
Case contents:

Metabolism of nutrients in physiological conditions; Changes in nutrient metabolism in the pathological conditions of the pancreas; Hypercalcemia in apoptosis; The impact of stress, alcohol and smoking on pathological changes in the pancreas; Diabetes mellitus; Complications (wounds and delays) in diabetes mellitus; Acute and chronic pancreatitis; Malignant changes of the pancreas; Molecular-genetic analysis of 18q chromosomes in pancreatic cancers; Embryonic mouse stem cells as an experimental model; Teratocarcinomas; Retroviruses as initiators of endocrinological disorders of the pancreas; Eceperimental animal (mice, rats) model diabetes mellitus in humans.
Learning outcomes: competences, knowledge, skills that the subject develops:

1. Analyze changes related to acute and chronic pathological conditions of the pancreas, as well as with malignant changes of this organ.
2. Review the previously known mechanisms of the occurrence of additional pathological complications accompanying diseases of the pancreas (tumor, apoptosis, neuropathy...),
3. Anticipate the possibilities and limitations of new forms of therapy.
4. Train to work on a mouse experimental diabetes model.
ECTS Credits 4
Lectures 5
Seminars (IS) 0
Exercises (E) 15
Altogether 20
The way of teaching and acquiring knowledge:

Regular attendance.
Ways of teaching and acquiring knowledge: (notes)
Monitoring and evaluating students (mark in fat printing only relevant categories) Attendance, Teaching activities
Rating method: Written exam
Mandatory literature:

Forquet F, Hadžija M, Semple JW, Speck E, Delovitch T Proc Natl Acad Sci USA 1994; 91: 3936-3940.

Katic M, Hadžija M, Wrischer M, Pavelić K Carcinogenesis 1999; 20: 1521-1527.

Pavelić K, Hadžija M Handbook of zeolite science and technology Marcel Dekker (ed) 1141-1172.
Textbook of diabetes, Blackwell scientific publications, Pickup J, Williams G (eds), 2001.
Emberyonic Stem cells, Humana Press, K. Turksen (ed), 2002.
Nettle I, Popović Hadžija M, Hadžija M & Aralica. G. Unsupervised segmentation of low-contrast multichannel images: discrimination of tissue components in microscopic images of unstained specimens. Scientific Reports, 5. 11576-1-11576-13

Popović Hadžija, Marijana; Korolija, Marina; Yemin, Nikolina; Pavković, Iva; Pavković, Pajica; Pope Medvidović, Edita; Hajj, Mirko. Polymorphisms in the IL-18 and IL-12B genes and their association with the clinic outcome in Croatian patients with Type 1 diabetes. 2013, Gene, 512:477- 481)

Popović Hadžija, Marijana; Korolija, Marina; Vukadinović, Gabriella; Hajj, Mirko. Association of TNF-a and PTPN22 SNPs with the risk and clinical outcome of type 1 diabetes. 2013, Central European Journal of Biology. 8; 513-519

Kopriva Ivica, Hadžija Mirko, Popović Hadžija Marijana, Korolija Marina, Cichocki Andrezej. Rational Variety Mapping for Contrast-Enhanced Nonlinear Unsupervised Segmentation of Multispectral Images of Unstained Specimen. The American Journal of Pathology, 2011: 179; 547-554

Korolija, Marina; Hajj, Mirko; Pope Medvidović, Edita; Pavković, Pajica; Kapitanović, Sanja; Pavlić Renar, Ivana; Popovic Hadžija, Marijana. Genetic evaluation of the TNF-α -238G>A and -308 G>A promoter polymorphisms in Croatian patients with type I diabetes. Human Immunology 2010: 71; 1228-1232)

Korolija, Marina; Pavlić Renar, Ivana; Hajj, Mirko; Pope Medvidović, Edita; Pavković, Pajica; Jokic, Mladen; Popovic Hadžija, Marijana. Association of PTPN22 C1858T and CTLA-4 A49G Polymorphisms with Type 1 Diabetes in Croatians. Diabetes Research and Clinical Practice 2009: 86; e54-e57. (2,231)
Supplementary (recommended) literature:

Hruban RH, Goggins M, Parsons J, Kern SE. Clinical Cancer Resaerch 6; 2969-2972: 2000.
Hall PM, Wilentz RE, Klerk W, Bornman PPC. Pathology 34; 504-517: 2002.
Chen JM, Ferec C. European Journal of Human Genetics 8; 473-479: 2000.
Heinmoller E, Bockholt A, Werther M, Ziemer M, Muller A, Ghadami BM, Ruschoff J. Pathology Research 199; 363-371: 2003.
Cavestro GM, Camparto G, Nouvenne A, Sereni SB, Frulloni L, Valle RD, Soliani P, Zanelli PF, Franze A, Di Mario F. JOP 6; 53-59: 2005.
Berna G, Leon-Quinto T, Ensenat-Waser R, Montanya E, Martin F, Soria B. Biomed Pharmacother 55; 206-212: 2001.
Servitja JM, Ferrer J. Diabetologia 47; 597-613: 2004.
Peck AB, Ramiya V. Transplant Immunology 12; 259-272: 2004.
Colman A. Seminars in Cell&developmental biology, xxx 2004.
How to monitor the quality and performance performance (evaluation):

Discussions with stedents and colleagues.
The success of the course will be evaluated annually by the joint expert committee of the Rudjer Boskovic Institute, the University of Dubrovnik and the University of Osijek.