Biomaterials (2102)

Izv.prof.dr.sc. Domagoj Drenjančević
Doc.dr.sc. Hrvoje Brkić

(DD) Faculty of Medicine, Josip Juraj Strossmayer University
(HB) Faculty of Dental Medicine and Health, J.J. Strossmayer University

Dr. sc. Maya Bogdan, zn. associate (MB422) 20%

To understand the dependence of chemical and biological properties of biomaterials on their composition and structure and to understand the influence of the interaction of biometheroids and microbial flora on human health as well as the possibilities of diagnostics, treatment and prevention of biomaterial infections.

Implants, Structure and forms of biomaterials (glass, ceramics, glass-ceramics, polymers, composites, thin layers, metals-steels; powder, grains, threads, foam, polycrystals). Properties of biomaterials (technical, chemical stability in the aqueous medium, chemical and biological reactions in the physiological environment, surface reactions, bioactivity). Types of biomaterials. Bioinerable, bioactive, biodegradable materials.
Therapeutic biomaterials. Dental supplies. Radioactive biomatrials (glass, metals in various forms). Application and technological development of biomaterials. Biologically oriented methods for tissue restoration. Tissue engineering-introduction. Materials used for the substrate in tissue engineering, their properties. Testing in vitro, in vivo, bioreactors. Regenerative bioactive materials.
The interaction of biomaterials with man's microbial flora and the formation of biofilms. Bacterial species associated with the formation of biofilms on biomaterials. Immune response to the formation of biofilms. Biomaterial infections – ubiquittal challenge: significance, detection methods, diagnostics, treatments and prevention. Antimicrobial resistance in biofilm. In vivo models for research into biofilm-related infections.

1. Explain the importance of knowing the composition, structure and properties of biomaterials as well as the conditions of preparation of biomaterials due to the impact of preparation on the physical and chemical properties of biomaterials.
2. Identify basic chemical and biological processes on the surface of bioinert, bioactive and biodegradable materials.
3. Assess the suitable properties of biomaterials for use.
4. Analyse biofilm testing models as well as microbial biofilm addiction and biomaterial infections.
5. Valorize methods of biofiome detection, diagnosis, treatment and prevention of biomaterial infection.

Preparation of seminar work

The seminars will include independent tasks and will complement individual thematic units covered in the lecture.

1. An Introduction to Bioceramics, ed. by L.L. Hench and J. Wilson, World Scientific Publishing Co. (1993)
2. Bioceramics: Materials and Applications, ed. by G. Fischman, A. Clare, L.L. Hench, The American Ceramic Society, Ceramic Transactions, vol.48, (1994)
3. Future Strategies for Tissue and Organ Replacement, ed. by J.M. Polak, L. L. Hench, P. Kemp, Imperial College Press, (2002)
4. L. L. Hench, Biomaterials: a forecast for the future, Biomaterials 19 (1998) 1419.
5. L. L. Hench, J.M. Polak, Third-Generation Biomedical Materials, Science 295 (2002) 1014.
6. L. G. Griffith, G. Naughton, Tissue Engineering-Current Challenge and Expanding Opportunities, Science 295 (2002) 1009.
7. J. E. White , D. E. Day, Rare Earth Aluminosilicate Glasses for in vivo Radiation Delivery, KeyEngineering Materials, 94-94 (1994) 181.
8. Online tutorial: Jerolimov V. and associates. Basics of dental materials / Jerolimov V. (your.). Zagreb : School of Dental Medicine, 2005.
9. Biofilms, infection, and antimicrobial therapy. Pace JL, Rupp M, Finch RG, editors. CRC Press, Taylor & Francis Group: Boca Raton, 2006.
10. Römling U, Kjelleberg S, Normark S, Nyman L, Uhlin BE, Åkerlund B.Microbial biofilm formation: a need to act. J Intern Med 2014;276:98-110.

1. S. F. Hulbert, J.C. Bokros, L. L. Hench, J. Wilson, and G. Heimke, "Ceramics in Clinical Applications, Past, Present and Future"; Ed. by P. Vincenzini. Elsevier Science Pub. B.V., Amsterdam, (1987).
2. L. L. Hench, "Bioactive Ceramics"; Ox. 523. Ed. by P. Ducheyne and J. Lemons. Annals N.Y. Acad. Sci. (1988).
3. J. Black, "Systemic Effects of Biomaterials," Biomaterials, 5 (1984) 11.
4. W. Hohland, W. Vogel, K. Naurnann, and J. Gummel, "Interface Reactions Between Machinable Bioactive Glass-Ceramics and Bone," J. Biomed. Mater. Res., 19 (1985) 303.
5.M. Jarcho, "Calcium Phosphate Ceramics as Hard Tissue Prosthetics," Clin. Orthop. Relat. Res., 157 (1981) 259.
6. D.C. Greenspan and L. L. Hench, "Chemical and Mechanical Behavior of Bioglass Coated Alumina," J. Biomed. The Maters. Res., 10 [4] (1976) 503.
7. The Bone-Biomaterial Interface, Ed. by J.E. Davies, University of Toronto Press (1991).
8. L. L. Hench, D. E. Clark, "Physical Chemistry of Glass Surfaces," J. Non-Cryst. Solids, 28 (1978) 83.
9. R. W. Douglas and T.M. El-Shamy, Reactions of Glasses with Aqueous Solutions," J. Amer. I'm ceasing. Soc., 50 [1] (1967) 1.
10. Francolini I, Donelli G. Prevention and control of biofilm-based medical-device-related infections. FEMS Immunol Med Microbiol 2010;59:227-38.

Verification of knowledge after each thematic unit. Seminars. Student presentations. Discussion with students.
The success of the course will be evaluated annually by the committee of the Ruđer Boskovic Institute, the University of Dubrovnik and the University of Osijek.